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Methods Mol Biol. 2016;1438:79-101. doi: 10.1007/978-1-4939-3661-8_5.

Generation of Human Liver Chimeric Mice for the Study of Human Hepatotropic Pathogens.

Author information

1
Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA.
2
Department of Molecular Biology, Princeton University, 110 Lewis Thomas Laboratory, Washington Road, Princeton, NJ, 08544, USA. aploss@princeton.edu.

Abstract

Human liver chimeric mice have become valuable tools for the study of human hepatotropic pathogens and for the investigation of metabolism and pharmacokinetics of novel drugs. The evolution of the underlying mouse models has been rapid in the past years. The diverse fields of applications of those model systems and their technical challenges will be discussed in this chapter.

KEYWORDS:

DMPK; Hepatitis B virus; Hepatitis C virus; Hepatitis delta virus; Human liver chimeric mice; Humanized mice; Malaria; Viral hepatitis

PMID:
27150085
DOI:
10.1007/978-1-4939-3661-8_5
[Indexed for MEDLINE]

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