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Pediatr Blood Cancer. 2016 Sep;63(9):1660-3. doi: 10.1002/pbc.26054. Epub 2016 May 3.

A Case of T-cell Acute Lymphoblastic Leukemia Relapsed As Myeloid Acute Leukemia.

Author information

1
Clinica di Oncoematologia Pediatrica dell'Azienda Ospedaliera di Padova, Padova, Italy.
2
Dipartimento di Salute della Donna e del Bambino, Università di Padova, Padova, Italy.
3
Laboratorio di Oncoematologia Pediatrica, Istituto di Ricerca Pediatrica, Fondazione Città della Speranza, Padova, Italy.
4
Centro di Ricerca Tettamanti, Clinica Pediatrica, Università di Milano, Bicocca, Milano, Italy.
5
Systems Biology Department, Columbia University, New York.
6
Department of Biomedical Informatics, Columbia University, New York.
7
Institute for Cancer Genetics, Columbia University, New York.
8
Department of Pathology, Columbia University, New York.
9
Department of Pediatrics, Columbia University, New York.

Abstract

A 4-year-old male with the diagnosis of T-cell acute lymphoblastic leukemia (T-ALL) relapsed after 19 months with an acute myeloid leukemia (AML). Immunoglobulin and T-cell receptor gene rearrangements analyses reveal that both leukemias were rearranged with a clonal relationship between them. Comparative genomic hybridization (Array-CGH) and whole-exome sequencing analyses of both samples suggest that this leukemia may have originated from a common T/myeloid progenitor. The presence of homozygous deletion of p16/INK4A, p14/ARF, p15/INK4B, and heterozygous deletion of WT1 locus remained stable in the leukemia throughout phenotypic switch, revealing that this AML can be genetically associated to T-ALL.

KEYWORDS:

T-ALL; switch lineage; whole-exome sequencing

PMID:
27149388
DOI:
10.1002/pbc.26054
[Indexed for MEDLINE]

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