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Thorac Cancer. 2016 Apr 26;7(3):348-54. doi: 10.1111/1759-7714.12317. Epub 2016 Feb 1.

Tissue-specific and plasma microRNA profiles could be promising biomarkers of histological classification and TNM stage in non-small cell lung cancer.

Author information

1
Department of Thoracic Surgery, West China Hospital Sichuan University Chengdu China; Toxicology Joint Laboratory between China Tobacco of Chuanyu Industrial Corporation and West China Hospital of Sichuan University Chengdu China.
2
Toxicology Joint Laboratory between China Tobacco of Chuanyu Industrial Corporation and West China Hospital of Sichuan University Chengdu China; Harmful Components and Tar Reduction in Cigarette Sichuan Key Laboratory Chengdu China.
3
Toxicology Joint Laboratory between China Tobacco of Chuanyu Industrial Corporation and West China Hospital of Sichuan University Chengdu China; Key Laboratory of Transplant Engineering and Immunology, Ministry of Health Regenerative Medicine Research Center, West China Hospital Sichuan University Chengdu China.
4
Department of Thoracic Surgery, West China Hospital Sichuan University Chengdu China; State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China; Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University Chengdu China.

Abstract

In a previous study, we determined that plasma miRNAs are potential biomarkers for cigarette smoking-related lung fibrosis. Herein, we determine whether tissue-specific and plasma miRNA profiles could be promising biomarkers for histological classification and TNM stage in non-small cell lung cancer (NSCLC). Plasma miRNA profiling preoperatively and seven days postoperatively, and cancer and normal tissue miRNA profiling were performed in NSCLC patients and matched healthy controls. There was a > twofold change for all signature miRNAs between the NSCLC patients and controls, with P values of < 0.05. We found that tissue-specific and plasma miR-211-3p, miR-3679-3p, and miR-4787-5p were promising biomarkers of different staging lung squamous cell carcinoma, and miR-3613-3p, miR-3675-3p, and miR-5571-5p were promising biomarkers of different staging lung adenocarcinoma. These results suggest that tissue-specific and plasma miRNAs could be potential biomarkers of histological classification and TNM stage in NSCLC.

KEYWORDS:

Biomarkers; NSCLC; TNM stage; histological classification; miRNAs

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