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Oncotarget. 2016 May 31;7(22):33340-9. doi: 10.18632/oncotarget.9043.

The platelet derived growth factor-B polymorphism is associated with risk of severe fever with thrombocytopenia syndrome in Chinese individuals.

Author information

1
State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, 100071, P. R. China.
2
Graduate School of Anhui Medical University, Hefei, 230032, P. R. China.
3
School of Public Health, Peking University, Beijing, 100191, P. R. China.
4
The 154 Hospital, People's Liberation Army, Xinyang, 464000, P. R. China.
5
The Shangcheng People's Hospital, Xinyang, 464000, P. R. China.
6
Shandong Provincial Center for Disease Control and Prevention, Jinan, 250001, P. R. China.

Abstract

BACKGROUND:

Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel bunyavirus named SFTS virus (SFTSV). We hypothesize that host genetic variations may contribute to susceptibility to SFTS.

RESULTS:

Compared with the rs1800818 AA genotype, AG + GG genotypes were significantly associated with increased susceptibility to SFTS (odds ratio, 1.66, 95% confidence interval = 1.28-2.16; P < 0.001). By using the ELISA assay, we observed that PDGF-BB concentration was significantly reduced in acute phase of patients than in the controls (P < 0.001) and recovered patients at 6 month (P = 0.007) and 12 month (P = 0.003). A persistently reduced PDGF-BB was also revealed from the SFTSV-infected C57BL/6J mice (P < 0.001). The rs1800818 G allele was associated with decreased serum PDGF-BB levels in SFTS patients at their early infection (P = 0.015). In accordance, the relative mRNA levels of the at-risk G allele of 1800818 were lower than those of the A allele in heterozygous cell from acute phase of SFTS patients. PDGF-B rs1800818 conferred no susceptibility to severe or fatal outcome in SFTS patients.

MATERIALS AND METHODS:

An initially small-scale case-control association study guided the selection of platelet derived growth factor-B (PDGF-B) rs1800818 in 1020 SFTS patients and 1353 controls. Functional analyses were conducted to verify the biological significance of rs1800818 polymorphism.

CONCLUSIONS:

Our findings suggest that the PDGF-B rs1800818 polymorphism might play a role in mediating the susceptibility to SFTS.

KEYWORDS:

PDGF-B; cytokines; polymorphism; severe fever with thrombocytopenia syndrome; susceptibility

PMID:
27147565
PMCID:
PMC5078099
DOI:
10.18632/oncotarget.9043
[Indexed for MEDLINE]
Free PMC Article

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