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Small. 2016 Sep;12(34):4707-12. doi: 10.1002/smll.201600263. Epub 2016 May 4.

External Magnetic Field-Induced Targeted Delivery of Highly Sensitive Iron Oxide Nanocubes for MRI of Myocardial Infarction.

Author information

1
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China.
2
Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, 100029, P. R. China.
3
School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, 450001, P. R. China.
4
Collaborative Innovation Center for Biotherapy, School of Medicine, Tsinghua University, Beijing, 100084, P. R. China.
5
Department of Radiology, Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing, 100029, P. R. China. fanzm120@126.com.
6
National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, P. R. China. xzhang@ipe.ac.cn.

Abstract

Magnetic field responsive nanocubes (MFRFs) are synthesized as nanoplatforms for external magnetic field-induced selective targeting of macrophages in the infarcted tissue and magnetic resonance imaging (MRI) monitoring. MFRFs have uniform size, favorable colloidal stability, and high magnetic properties. Under the influence of external magnetic field, MFRFs perform qualitative and quantitative MRI of myocardial infarction.

KEYWORDS:

external magnetic fields; iron oxide nanocubes; magnetic field responsive; magnetic resonance imaging; myocardial infarction

PMID:
27147555
DOI:
10.1002/smll.201600263
[Indexed for MEDLINE]

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