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Fundam Clin Pharmacol. 1989;3(1):11-7.

Effect of renal failure on the pharmacokinetics of ethyl loflazepate (Victan) in man.

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INSERM U 278, Faculté de Pharmacie, Marseille, France.


The kinetics of ethyl loflazepate were studied in patients with various degrees of renal failure. A strong correlation was noted between urinary excretion of metabolite loflazepate and creatinine clearance. In contrast, elimination half-life and total plasma clearance of the sum of loflazepate + descarboxyloflazepate seemed to be independent of the degree of renal impairment. These results indicate the absence of a risk of accumulation of the 2 main and active metabolites of ethyl loflazepate in patients with renal failure.

[Indexed for MEDLINE]

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