Format

Send to

Choose Destination
Am J Clin Nutr. 2016 Jun;103(6):1497-506. doi: 10.3945/ajcn.115.127092. Epub 2016 May 4.

Alcohol consumption and survival of colorectal cancer patients: a population-based study from Germany.

Author information

1
Division of Clinical Epidemiology and Aging Research, v.walter@dkfz.de.
2
Division of Clinical Epidemiology and Aging Research.
3
Departments of General, Visceral and Transplantation Surgery and.
4
Unit of Molecular Tumor Pathology, Pathology, Institute of Pathology, University Hospital, Heidelberg, Germany; and.
5
Institute of Pathology, Charité University Medicine, Berlin, Germany.
6
Division of Cancer Epidemiology, and.
7
Division of Clinical Epidemiology and Aging Research, German Cancer Consortium, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, National Center for Tumor Diseases, Heidelberg, Germany;

Abstract

BACKGROUND:

Studies on the association between alcohol consumption and colorectal cancer (CRC) prognosis have yielded inconsistent results.

OBJECTIVE:

The associations of lifetime and 1-y prediagnostic alcohol consumption with relevant prognostic outcomes were evaluated in a large population-based cohort of CRC patients.

DESIGN:

In 2003-2010, 3121 patients diagnosed with CRC were interviewed on sociodemographic and lifestyle factors, medication, and comorbidities. Cancer recurrence, vital status, and cause of death were documented for a median follow-up time of 4.8 y. With the use of Cox proportional hazard regression, associations between lifetime and recent alcohol consumption and overall, CRC-specific, recurrence-free, and disease-free survival were analyzed.

RESULTS:

In this patient cohort with a median age of 69 y at diagnosis, lifetime abstainers showed poorer overall [adjusted HR (aHR): 1.25; 95% CI: 1.03, 1.52] and CRC-specific (aHR: 1.37; 95% CI: 1.10, 1.70) survival than lifetime light drinkers (women: >0-12 g/d; men: >0-24 g/d). Lifetime heavy drinkers showed poorer overall (aHR: 1.37; 95% CI: 1.06, 1.78) and disease-free (aHR: 1.38; 95% CI: 1.09, 1.74) survival. Alcohol abstaining in the year before diagnosis was associated with poorer overall (aHR: 1.42; 95% CI: 1.20, 1.68), CRC-specific (aHR: 1.38; 95% CI: 1.13, 1.68), and disease-free (aHR: 1.23; 95% CI: 1.05, 1.44) survival. Lifetime abstainers with nonmetastatic disease showed poorer CRC-specific (aHR: 1.48; 95% CI: 1.10, 2.00) and recurrence-free (aHR: 1.32; 95% CI: 1.02, 1.70) survival. Wine abstaining but not beer or liquor abstaining was associated with poorer survival. Associations between alcohol consumption and prognosis varied according to presence of diabetes and age.

CONCLUSIONS:

Prediagnostic alcohol abstaining and heavy drinking were associated with poorer survival after a CRC diagnosis than light drinking. The protective effects of light consumption might be restricted to wine, and associations might differ according to age and presence of diabetes mellitus.

KEYWORDS:

alcohol consumption; colorectal neoplasms; prognosis; recurrence; survival

PMID:
27146651
DOI:
10.3945/ajcn.115.127092
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center