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Chin J Integr Med. 2017 Dec;23(12):908-915. doi: 10.1007/s11655-016-2500-7. Epub 2016 May 4.

Protective effects of traditional Tibetan medicine Zuo-Mu-A Decoction () on the blood parameters and myocardium of high altitude polycythemia model rats.

Author information

1
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China.
2
Tibetan Traditional Medical College, Lhasa, 850000, China. bairizerendawa@163.com.
3
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, 100029, China. yutianyuan@sina.com.
4
Department of Tuina, Beijing Massage Hospital, Beijing, 100035, China.
5
Information Center, Beijing University of Chinese Medicine, Beijing, 100029, China.
6
Tibet Academy of Tibetan Medicine, Lhasa, 850000, China.
7
Tibetan Traditional Medical College, Lhasa, 850000, China.
8
Center of Scientific Experiment, Beijing University of Chinese Medicine, Beijing, 100029, China.

Abstract

OBJECTIVE:

To explore the protective effects of Tibetan medicine Zuo-Mu-A Decoction (, ZMAD) on the blood parameters and myocardium of high altitude polycythemia (HAPC) model rats.

METHODS:

Forty male Wistar rats were randomly divided into 4 groups by a random number table, including the normal, model, Rhodiola rosea L. (RRL) and ZMAD groups (10 in each group). Every group was raised in Lhasa to create a HAPC model except the normal group. After modeling, rats in the RRL and the ZMAD groups were administered intragastrically with RRL (20 mL/kg) and ZMAD (7.5 mL/kg) once a day for 2 months, respectively; for the normal and the model groups, 5 mL of distilled water was administered intragastrically instead of decoction. Then routine blood and hematologic rheology parameters were taken, levels of erythropoietin and 8-hydroxy-2'-deoxyguanosine (8-OHdG) were tested, and ultrastructural change in the left ventricular myocardium was observed using transmission electron microscopy.

RESULTS:

Compared with the model group, ZMAD significantly reduced the red blood cell count, hemoglobin levels, whole blood viscosity at low/middle shear rates, plasma viscosity, erythrocyte electrophoretic time, erythropoietin and 8-OHdG levels, and also increased the erythrocyte deformation index (P<0.05). There was no difference in all results between the RRL and the ZMAD groups. The cardiac muscle fibers were well-protected, mitochondrial matrix swelled mildly and ultrastructure changes were less prominent in the ZMAD group compared with the model group.

CONCLUSION:

ZMAD has significant protective effects on the blood parameters against HAPC, and also has the beneficial effect in protecting against myocardial injury.

KEYWORDS:

erythropoietin; hematology; high altitude polycythemia; myocardium; traditional medicine

PMID:
27145942
DOI:
10.1007/s11655-016-2500-7
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