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Annu Rev Biochem. 2016 Jun 2;85:515-42. doi: 10.1146/annurev-biochem-060815-014546. Epub 2016 Apr 25.

Ice-Binding Proteins and Their Function.

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Institute of Biochemistry, Food Science and Nutrition, Robert H. Smith Faculty of Agricultural, Food and Environment, The Hebrew University of Jerusalem, Rehovot 7610001, Israel; email: ,
Department of Biomedical and Molecular Science, Queen's University, Kingston, Ontario K7L 3N6, Canada; email:


Ice-binding proteins (IBPs) are a diverse class of proteins that assist organism survival in the presence of ice in cold climates. They have different origins in many organisms, including bacteria, fungi, algae, diatoms, plants, insects, and fish. This review covers the gamut of IBP structures and functions and the common features they use to bind ice. We discuss mechanisms by which IBPs adsorb to ice and interfere with its growth, evidence for their irreversible association with ice, and methods for enhancing the activity of IBPs. The applications of IBPs in the food industry, in cryopreservation, and in other technologies are vast, and we chart out some possibilities.


anchored clathrate waters; antifreeze proteins; ice-binding site; ice-structuring proteins; thermal hysteresis

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