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Neuroreport. 2016 Jun 15;27(9):671-6. doi: 10.1097/WNR.0000000000000594.

Improvement of memory recall by quercetin in rodent contextual fear conditioning and human early-stage Alzheimer's disease patients.

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Departments of aNeurobiology bNeurology and Geriatrics cPharmacy, Gifu University Graduate School of Medicine dLong Term Care Health Facility Senjyu Nagomino eChikaishi Clinic fAsahi University, Gifu gHokkaido Agricultural Research Center, National Agriculture and Food Research Organization (NARO) hHokkaido Research Organization, Sapporo iRIKEN Center for Sustainable Resource Science, Yokohama jNational Food Research Institute, NARO, Tsukuba, Japan.


Patients with Alzheimer's disease (AD) experience a wide array of cognitive deficits, which typically include the impairment of explicit memory. In previous studies, the authors reported that a flavonoid, quercetin, reduces the expression of ATF4 and delays memory deterioration in an early-stage AD mouse model. In the present study, the effects of long-term quercetin intake on memory recall were assessed using contextual fear conditioning in aged wild-type mice. In addition, the present study examined whether memory recall was affected by the intake of quercetin-rich onion (a new cultivar of hybrid onion 'Quergold') powder in early-stage AD patients. In-vivo analysis indicated that memory recall was enhanced in aged mice fed a quercetin-containing diet. Memory recall in early-stage AD patients, determined using the Revised Hasegawa Dementia Scale, was significantly improved by the intake of quercetin-rich onion (Quergold) powder for 4 weeks compared with the intake of control onion ('Mashiro' white onion) powder. These results indicate that quercetin might influence memory recall.

[Indexed for MEDLINE]

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