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Structure. 2016 May 3;24(5):653-655. doi: 10.1016/j.str.2016.04.004.

Production of Heteromeric Transmembrane Receptors with Defined Subunit Stoichiometry.

Author information

1
Cold Spring Harbor Laboratory, W. M. Keck Structural Biology Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA.
2
Cold Spring Harbor Laboratory, W. M. Keck Structural Biology Laboratory, One Bungtown Road, Cold Spring Harbor, NY 11724, USA. Electronic address: furukawa@cshl.edu.

Abstract

Signal transduction across cell membranes often requires assembly of heteromeric receptors with defined stoichiometry. In this issue of Structure, Morales-Perez et al. (2016) present elegant methods for the expression of heteromeric nicotinic acetylcholine receptors with a defined α4β2 stoichiometry involving controlled baculovirus-mediated transduction and subunit counting by measurement of two fluorescent signals.

PMID:
27145073
PMCID:
PMC5266497
DOI:
10.1016/j.str.2016.04.004
[Indexed for MEDLINE]
Free PMC Article

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