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Contact Dermatitis. 2016 Nov;75(5):285-289. doi: 10.1111/cod.12598.

Concomitant contact allergies to formaldehyde, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, and fragrance mixes I and II.

Author information

1
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 214 28, Malmö, Sweden. ann.ponten@med.lu.se.
2
Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, 214 28, Malmö, Sweden.

Abstract

BACKGROUND:

Contact allergies to the preservatives formaldehyde and methylchloroisothiazolinone (MCI)/methylisothiazolinone (MI) have been reported to appear together at a statistically significant level. Recently, revisions concerning the patch test preparations of MCI/MI, MI and formaldehyde have been recommended for the European baseline series.

AIM:

To investigate (i) the number of concomitant contact allergies to the preservatives, (ii) the number of concomitant contact allergies to the preservatives and the fragrance mixes (FM I and FM II) and (iii) gender differences.

METHODS:

Patients tested with the Swedish baseline series during the period 2012-2014 at the Department of Occupational and Environmental Dermatology in Malmö, Sweden were investigated.

RESULTS:

2165 patients were patch tested with the baseline series (34% males and 66% females). Contact allergies to formaldehyde and MCI/MI and/or MI were significantly associated (p < 0.001). The associations between contact allergy to MCI/MI and/or MI and FM I and/or FM II, and between formaldehyde and FM I and/or FM II as well as, were statistically significant (p < 0.001).

CONCLUSION:

Contact allergies to formaldehyde and MCI/MI and/or MI are significantly associated, as well as contact allergies to these preservatives and fragrance allergy. Males and females do not differ significantly concerning contact allergy to fragrances.

KEYWORDS:

contact allergy; fragrances; preservatives; sex

PMID:
27145058
DOI:
10.1111/cod.12598
[Indexed for MEDLINE]

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