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Gastroenterology. 2016 Feb 18. pii: S0016-5085(16)00222-5. doi: 10.1053/j.gastro.2016.02.031. [Epub ahead of print]

Bowel Disorders.

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Institute of Functional and Motor Digestive Disorders, Centro Médico Teknon, Barcelona, Spain.
Division of Gastroenterology & Hepatology, Dartmouth-Hitchcock Medical Center, Lebanon, NH. USA.
David Geffen School of Medicine at UCLA, Los Angeles, CA. USA.
University of Michigan Health System, Ann Arbor, MI. USA.
Beth Israel Deaconess Medical Center, Harvard Medical School, Boston MA. USA.
Institute of Medicine, Department of Internal Medicine & Clinical Nutrition, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Cantab, University of Nottingham, UK.


Functional bowel disorders are highly prevalent disorders found worldwide. These disorders have the potential to affect all members of society, regardless of age, gender, race, creed, color or socioeconomic status. Improving our understanding of functional bowel disorders (FBD) is critical as they impose a negative economic impact to the global health care system in addition to reducing quality of life. Research in the basic and clinical sciences during the past decade has produced new information on the epidemiology, etiology, pathophysiology, diagnosis and treatment of FBDs. These important findings created a need to revise the Rome III criteria for FBDs, last published in 2006. This manuscript classifies the FBDs into five distinct categories: irritable bowel syndrome (IBS); functional constipation (FC); functional diarrhea (FDr); functional abdominal bloating/distention (FAB/D); and unspecified FBD (U-FBD). Also included in this article is a new sixth category, opioid induced constipation (OIC) which is distinct from the functional bowel disorders (FBDs). Each disorder will first be defined, followed by sections on epidemiology, rationale for changes from prior criteria, clinical evaluation, physiologic features, psychosocial features and treatment. It is the hope of this committee that this new information will assist both clinicians and researchers in the decade to come.


abdominal pain; bloating; constipation; diarrhea; distension; functional bowel disorders; irritable bowel syndrome

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