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Growth Factors. 2016 Feb;34(1-2):51-63. doi: 10.3109/08977194.2016.1170679. Epub 2016 May 4.

Secretion pathway of liver IGF-1 via JAK2/STAT3 in chick embryo under the monochromatic light.

Author information

1
a Laboratory of Anatomy of Domestic Animals , College of Animal Medicine, China Agricultural University , Haidian , Beijing , China.

Abstract

This study reveals mechanism of monochromatic light on the IGF-1 secretion of chick embryo liver. The chick embryos were incubated and exposed to continuous red, green, blue light or a dark environment. Compared to other light-treated groups, green light increased IGF-1 and melatonin concentrations both in plasma and liver, and Mel1a, Mel1b and Mel1c receptors expressions in liver but decreased p-JAK2, p-STAT3 and ROS in liver. IGF-1 had a positive correlation with melatonin, but a negative relevance with p-JAK2 and p-STAT3. In vitro, the IGF-1 level in the hepatocyte supernatant was enhanced by melatonin with lower p-JAK2/p-STAT3 and ROS levels, which was suppressed by Mel1c antagonist but not Mel1a/Mel1b or Mel1b antagonists. AG490 (JAK/STAT inhibitor) promoted role of melatonin-Mel1c modulated IGF-1 secretion. These results suggest the antioxidant effect of melatonin mediated the green light-enhanced IGF-1 secretion of chick embryo liver through Mel1c receptor to inhibit the JAK2/STAT3 pathway.

KEYWORDS:

IGF-1; JAK2/STAT3; Monochromatic light; chick embryo; liver

PMID:
27144424
DOI:
10.3109/08977194.2016.1170679
[Indexed for MEDLINE]

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