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Nutr Cancer. 2016 May-Jun;68(4):535-44. doi: 10.1080/01635581.2016.1158300. Epub 2016 May 4.

The Potential Role of Probiotics in Cancer Prevention and Treatment.

Yu AQ1,2,3, Li L4.

Author information

1
a Institute of Psychology, Chinese Academy of Sciences , Beijing , China.
2
b Graduate School of Chinese Academy of Sciences , Beijing , China.
3
c Shanghai Lida Polytechnic Institute , Shanghai , China.
4
d Department of Obstetrics and Gynecology , Yantai Affiliated Hospital of Binzhou Medical University , Yantai , China.

Abstract

The human gut microbiota has a significant effect on many aspects of human physiology such as metabolism, nutrient absorption, and immune function. Imbalance of the microbiota has been implicated in many disorders including inflammatory bowel disease, obesity, asthma, psychiatric illnesses, and cancers. As a kind of functional foods, probiotics have been shown to play a protective role against cancer development in animal models. Clinical application of probiotics indicated that some probiotic strains could diminish the incidence of postoperative inflammation in cancer patients. Chemotherapy or radiotherapy-related diarrhea was relieved in patients who were administered oral probiotics. The present review summarizes the up-to-date studies on probiotic effects and the underlying mechanisms related to cancer. At present, it is commonly accepted that most commercial probiotic products are generally safe and can improve the health of the host. By modulating intestinal microbiota and immune response, some strains of probiotics can be used as an adjuvant for cancer prevention or/and treatment.

PMID:
27144297
DOI:
10.1080/01635581.2016.1158300
[Indexed for MEDLINE]

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