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Trends Parasitol. 2016 Jul;32(7):515-521. doi: 10.1016/j.pt.2016.04.002. Epub 2016 Apr 30.

Epigenetics: A New Model for Intracellular Parasite-Host Cell Regulation.

Author information

1
Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, Canada. Electronic address: robm@mail.ubc.ca.
2
Immunity and Infection Research Centre, Vancouver Coastal Health Research Institute, Department of Medical Genetics, University of British Columbia, Vancouver, Canada.
3
Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Human Early Learning Partnership, School of Population and Public Health, Department of Medical Genetics, University of British Columbia, Vancouver, Canada.

Abstract

Intracellular protozoan parasites are an extremely important class of pathogens that cause a spectrum of diseases in human and animal hosts. There is a growing body of evidence suggesting that protozoan parasites, like other prokaryotic and viral pathogens, manipulate host cells via epigenetic modifications of the host genome that alter transcription and corresponding signaling pathways. In light of these data, we examine the role of epigenetics in downregulation of host macrophages by Leishmania that could potentially lead to a permanent state of inactivation, thus favoring pathogen survival and disease progression.

KEYWORDS:

DNA methylation; Leishmania; Theileria; Toxoplasma; epigenetics; exosomes.; histone modification; ncRNA

PMID:
27142564
DOI:
10.1016/j.pt.2016.04.002
[Indexed for MEDLINE]

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