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Breast Cancer Res. 2016 May 3;18(1):45. doi: 10.1186/s13058-016-0701-9.

Raised mammographic density: causative mechanisms and biological consequences.

Author information

1
Faculties of Life and Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK.
2
Faculties of Life and Medical and Human Sciences, University of Manchester, Oxford Road, Manchester, M13 9PT, UK. cstreuli@manchester.ac.uk.

Abstract

High mammographic density is the most important risk factor for breast cancer, after ageing. However, the composition, architecture, and mechanical properties of high X-ray density soft tissues, and the causative mechanisms resulting in different mammographic densities, are not well described. Moreover, it is not known how high breast density leads to increased susceptibility for cancer, or the extent to which it causes the genomic changes that characterise the disease. An understanding of these principals may lead to new diagnostic tools and therapeutic interventions.

PMID:
27142210
PMCID:
PMC4855337
DOI:
10.1186/s13058-016-0701-9
[Indexed for MEDLINE]
Free PMC Article

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