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Reprod Toxicol. 2016 Jul;62:77-86. doi: 10.1016/j.reprotox.2016.04.021. Epub 2016 Apr 30.

Maternal marijuana use has independent effects on risk for spontaneous preterm birth but not other common late pregnancy complications.

Author information

1
Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia. Electronic address: shalem.leemaqz@adelaide.edu.au.
2
Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia; Department of Obstetrics and Gynaecology, Lyell McEwin Hospital, Elizabeth, South Australia, Australia. Electronic address: gustaaf.dekker@adelaide.edu.au.
3
Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand. Electronic address: l.mccowan@auckland.ac.nz.
4
The Irish Centre for Fetal and Neonatal Translational Research (INFANT), University College Cork, Ireland. Electronic address: L.Kenny@ucc.ie.
5
Maternal & Fetal Heath Research Centre, Manchester Academic Health Science Centre, University of Manchester, Central Manchester NHS Trust, Manchester, United Kingdom. Electronic address: jenny.myers@manchester.ac.uk.
6
Department of Women's & Children's Health, University of Leeds, Leeds, United Kingdom. Electronic address: n.a.b.simpson@leeds.ac.uk.
7
Division of Women's Health, King's College London, London, United Kingdom. Electronic address: lucilla.poston@kcl.ac.uk.
8
Robinson Research Institute, School of Medicine, University of Adelaide, Adelaide, South Australia 5005, Australia. Electronic address: claire.roberts@adelaide.edu.au.

Abstract

Widespread legalisation of marijuana raises safety concerns for its use in pregnancy. This study investigated the association of marijuana use prior to and during pregnancy with pregnancy outcomes in a prospective cohort of 5588 nulliparous women from the international SCOPE study. Women were assessed at 15±1 and 20±1 weeks' gestation. Cases [278 Preeclampsia, 470 gestational hypertension, 633 small-for-gestational-age, 236 spontaneous preterm births (SPTB), 143 gestational diabetes] were compared separately with 4114 non-cases. Although the numbers are small, continued maternal marijuana use at 20 weeks' gestation was associated with SPTB independent of cigarette smoking status [adj OR 2.28 (95% CI:1.45-3.59)] and socioeconomic index (SEI) [adj OR 2.17 (95% CI:1.41-3.34)]. When adjusted for maternal age, cigarette smoking, alcohol and SEI, continued maternal marijuana use at 20 weeks' gestation had a greater effect size [adj OR 5.44 (95% CI 2.44-12.11)]. Our data indicate that increasing use of marijuana among young women of reproductive age is a major public health concern.

KEYWORDS:

BMI; Marijuana; Pregnancy outcome; Smoking; Spontaneous preterm birth

PMID:
27142189
DOI:
10.1016/j.reprotox.2016.04.021
[Indexed for MEDLINE]
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