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Dev Pharmacol Ther. 1989;12(2):65-9.

Caffeine pharmacokinetics in preterm infants older than 2 weeks.

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  • 1Department of Pediatrics, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey.


We studied 17 preterm infants receiving caffeine, and measured their plasma levels of caffeine and the theophylline metabolite by high-pressure liquid chromatography. The half-life was calculated by computer analysis using the least-square method. The mean gestational age of our patients was 29.7 +/- 1.9 weeks (mean +/- SD) and they were studied at 20.7 +/- 6.6 days (mean +/- SD) postnatal age. The caffeine half-life was 52.03 +/- 23.87 h (means +/- SD) and the theophylline half-life was 77.04 +/- 65.01 h (mean +/- SD).

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