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Oncoimmunology. 2015 Aug 31;5(3):e1083672. eCollection 2016 Mar.

Novel understanding of self-reactive T cells.

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Center for Cancer Immune Therapy (CCIT), Department of Hematology, Copenhagen University Hospital , Herlev, Denmark.


In a recent issue of Immunity, Mark Davis and colleagues describe that thymic selection does not eliminate but prunes self-reactive T cell clones. Self-reactive T cells are a natural part of the T-cell repertoire and may be important in the fight against pathogens in addition to being important immune regulators.


Anti-Tregs; CD8; IDO; PD-L1; self-reactive T cells; thymic selection

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