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Can J Neurol Sci. 2016 Jul;43(4):462-71. doi: 10.1017/cjn.2016.35. Epub 2016 May 3.

Eligibility Criteria for Deep Brain Stimulation in Parkinson's Disease, Tremor, and Dystonia.

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1Morton and Gloria Shulman Movement Disorders Centre and the Edmond J. Safra Program in Parkinson's Disease,Toronto Western Hospital,University Health Network,Toronto,Ontario,Canada.
3André-Barbeau Movement Disorders Unit Service of Neurology,Centre Hospitalier de l'Université de Montréal and Department of Medicine,Université de Montréal,Montréal,Québec,Canada.
4Division of Neurosurgery,University of British Columbia,Vancouver,British Columbia,Canada.


In this review, the available evidence to guide clinicians regarding eligibility for deep brain stimulation (DBS) in the main conditions in which these forms of therapy are generally indicated-Parkinson's disease (PD), tremor, and dystonia-is presented. In general, the literature shows that DBS is effective for PD, essential tremor, and idiopathic dystonia. In these cases, key points in patient selection must include the level of disability and inability to manage symptoms using the best available medical therapy. Results are, however, still not optimal when dealing with other aetiologies, such as secondary tremors and symptomatic dystonia. Also, in PD, issues such as age and neuropsychiatric profile are still debatable parameters. Overall, currently available literature is able to guide physicians on basic aspects of patient selection and indications for DBS; however, a few points are still debatable and controversial. These issues should be refined and clarified in future studies.


Parkinson’s disease; deep brain stimulation; dystonia; essential tremor; movement disorders; surgery; tremor

[Indexed for MEDLINE]

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