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Curr Drug Targets. 2016;17(15):1707-1713.

Future Targets in Endothelial Biology: Endothelial Cell to Mesenchymal Transition.

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Yale Cardiovascular Research Center, 300 George St New Haven, CT 06511, USA.


Endothelial to mesenchymal transition (EndMT) is a poorly understood phenomenon that results in normal endothelial cells acquiring a mesenchymal phenotype. EndMT has been observed in a number of pathological conditions, from cancer to fibrosis to cardiovascular disease and the process itself may play an important mechanistic role in the development of these disease states.

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