Two new chromosomal abnormalities in chronic myelogenous leukemia 46,XY,t(9;15;22)(q34;q22;q11) and 46,XY,t(6;9;12;22)(p21;q34;q24;q11)

G M Ramirez; M J Macera; R S Verma

doi:10.1016/0165-4608(89)90171-4

Two new chromosomal abnormalities in chronic myelogenous leukemia 46,XY,t(9;15;22)(q34;q22;q11) and 46,XY,t(6;9;12;22)(p21;q34;q24;q11)

Cancer Genet Cytogenet. 1989 Mar;38(1):115-9. doi: 10.1016/0165-4608(89)90171-4.

Authors

G M Ramirez¹, M J Macera, R S Verma

Affiliation

¹ Division of Genetics, Long Island College Hospital, Brooklyn, NY 11201.

PMID: 2713807
DOI: 10.1016/0165-4608(89)90171-4

Abstract

Two new variant cases of chronic myelogenous leukemia (CML) are presented. The first case is a 19-year-old male with a 46,XY,t(9;15;22)(q34;q22;q11) karyotype. The second case is a 75-year-old man with a 46,XY,t(6;9;12;22)(p21;q34;q24;q11) karyotype. In both cases, the prognosis was no different from those cases of CML with the standard t(9;22) as the only abnormality. We recommend that all unusual translocations be reported.

Publication types

Case Reports
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Aged
Chromosomes, Human, Pair 22
Chromosomes, Human, Pair 9
Humans
Karyotyping
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / genetics*
Male
Translocation, Genetic*