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Curr Opin Clin Nutr Metab Care. 2016 Jul;19(4):300-2. doi: 10.1097/MCO.0000000000000291.

Impact of intermittent fasting on glucose homeostasis.

Author information

1
Department of Kinesiology and Nutrition, University of Illinois at Chicago, Chicago, Illinois, USA.

Abstract

PURPOSE OF REVIEW:

This article provides an overview of the most recent human trials that have examined the impact of intermittent fasting on glucose homeostasis.

RECENT FINDINGS:

Our literature search retrieved one human trial of alternate day fasting, and three trials of Ramadan fasting published in the past 12 months. Current evidence suggests that 8 weeks of alternate day fasting that produces mild weight loss (4% from baseline) has no effect on glucose homeostasis. As for Ramadan fasting, decreases in fasting glucose, insulin, and insulin resistance have been noted after 4 weeks in healthy normal weight individuals with mild weight loss (1-2% from baseline). However, Ramadan fasting may have little impact on glucoregulatory parameters in women with polycystic ovarian syndrome who failed to observe weight loss.

SUMMARY:

Whether intermittent fasting is an effective means of regulating glucose homeostasis remains unclear because of the scarcity of studies in this area. Large-scale, longer-term randomized controlled trials will be required before the use of fasting can be recommended for the prevention and treatment of metabolic diseases.

PMID:
27137896
DOI:
10.1097/MCO.0000000000000291
[Indexed for MEDLINE]

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