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Environ Toxicol Pharmacol. 2016 Jun;44:99-106. doi: 10.1016/j.etap.2016.04.015. Epub 2016 Apr 27.

The effect of occupational exposure on pro/antioxidant balance in the blood of non-smoking and smoking smelters with diabetes.

Author information

1
Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: a_bizon@op.pl.
2
Professor Emeritus from Department and Clinic of Internal and Occupational Diseases and Hypertension, Wroclaw Medical Uniwersity, Borowska 213, 50-556 Wrocław, Poland.
3
Faculty of Medicine, Wroclaw Medical University, Wrocław, Poland.
4
Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland.
5
Department of Biomedical and Environmental Analysis, Wroclaw Medical University, Borowska 211, 50-556 Wrocław, Poland. Electronic address: halina.milnerowicz@umed.wroc.pl.

Abstract

Arsenic, lead and cadmium, potent environmental toxicants have been reported to induce diabetes mellitus, but their potential biological mechanism(s) have not been much investigated. The present study was designed to correlate parameters of pro/antioxidant balance with occupational exposure on heavy metals and smoking in smelters with diabetes compared on control group. The results showed a significant increase in the concentration of arsenic, cadmium and lead in the blood and urine of smelters, while smoking caused a further increase in the concentration of these metals. Increasing γ-glutamyltransferase activity and lead concentration due to occupational exposure in copper foundry, tobacco smoke and co-existing diabetes were observed. Also these factors have synergistic effects on metallothionein and glutathione concentrations as well as glutathione dependent enzymes activities. Our data suggests that sub-chronic arsenic, lead and cadmium exposure induces diabetic condition which may be mediated due to increased oxidative stress in blood.

KEYWORDS:

Diabetes; Occupational exposure; Pro/antioxidant balance; Smelters; Smoking

PMID:
27137107
DOI:
10.1016/j.etap.2016.04.015
[Indexed for MEDLINE]

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