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Molecules. 2016 Apr 29;21(5). pii: E539. doi: 10.3390/molecules21050539.

Biodegradable Polymers and Stem Cells for Bioprinting.

Author information

1
Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China. lmj15@mails.tsinghua.edu.cn.
2
Center of Organ Manufacturing, Department of Mechanical Engineering, Tsinghua University, Beijing 100084, China. wangxiaohong@tsinghua.edu.cn.
3
Center of 3D printing & Organ Manufacturing, Department of Tissue Engineering, China Medical University (CMU), Shenyang 110122, China. wangxiaohong@tsinghua.edu.cn.

Abstract

It is imperative to develop organ manufacturing technologies based on the high organ failure mortality and serious donor shortage problems. As an emerging and promising technology, bioprinting has attracted more and more attention with its super precision, easy reproduction, fast manipulation and advantages in many hot research areas, such as tissue engineering, organ manufacturing, and drug screening. Basically, bioprinting technology consists of inkjet bioprinting, laser-based bioprinting and extrusion-based bioprinting techniques. Biodegradable polymers and stem cells are common printing inks. In the printed constructs, biodegradable polymers are usually used as support scaffolds, while stem cells can be engaged to differentiate into different cell/tissue types. The integration of biodegradable polymers and stem cells with the bioprinting techniques has provided huge opportunities for modern science and technologies, including tissue repair, organ transplantation and energy metabolism.

KEYWORDS:

bioprinting; gelatin based hydrogels; organ manufacturing; stem cells; tissue engineering

PMID:
27136526
PMCID:
PMC6274354
DOI:
10.3390/molecules21050539
[Indexed for MEDLINE]
Free PMC Article

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