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Adv Mater. 2016 Jul;28(25):5072-9. doi: 10.1002/adma.201506428. Epub 2016 May 2.

Ultrasmall Biocompatible WO3- x Nanodots for Multi-Modality Imaging and Combined Therapy of Cancers.

Wen L1,2, Chen L1,2, Zheng S1,2, Zeng J1,2, Duan G1,2, Wang Y1,2, Wang G1,2, Chai Z1,2, Li Z1,2, Gao M1,2,3.

Author information

1
Center for Molecular Imaging and Nuclear Medicine, School for Radiological and Interdisciplinary Sciences (RAD-X), Soochow University, Suzhou, 215123, P. R. China.
2
Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou, 215123, P. R. China.
3
Institute of Chemistry, Chinese Academy of Sciences, Bei Yi Jie 2, Zhongguancun, Beijing, 100190, P. R. China.

Abstract

Ultrasmall biocompatible WO3 - x nanodots with an outstanding X-ray radiation sensitization effect are prepared, and demonstrated to be applicable for multi-modality tumor imaging through computed tomography and photoacoustic imaging (PAI), and effective cancer treatment combining both photothermal therapy and radiation therapy.

KEYWORDS:

combined tumor therapy; multi-modality imaging; radiation sensitization; tungsten oxide; ultrasmall nanodots

PMID:
27136070
DOI:
10.1002/adma.201506428
[Indexed for MEDLINE]

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