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Curr Opin Biotechnol. 2016 Aug;40:139-148. doi: 10.1016/j.copbio.2016.04.005. Epub 2016 Apr 29.

Synthetic biology-application-oriented cell engineering.

Author information

1
Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland.
2
Department of Biosystems Science and Engineering, ETH Zurich, Mattenstrasse 26, CH-4058 Basel, Switzerland; University of Basel, Faculty of Science, Mattenstrasse 26, CH-4058 Basel, Switzerland. Electronic address: fussenegger@bsse.ethz.ch.

Abstract

Synthetic biology applies engineering principles to biological systems and reprograms living cells to perform novel and improved functions. In this review, we first provide an update of common tools and design principles that enable user-defined control of mammalian cell activities with spatiotemporal precision. Next, we demonstrate some examples of how engineered mammalian cells can be developed towards biomedical solutions in the context of real-world problems.

PMID:
27135809
DOI:
10.1016/j.copbio.2016.04.005
[Indexed for MEDLINE]

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