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Platelets. 2016 Sep;27(6):505-11. doi: 10.3109/09537104.2016.1171304. Epub 2016 May 2.

Glycans and the platelet life cycle.

Author information

1
a Aflac Cancer and Blood Disorders Center, Department of Pediatrics , Emory University School of Medicine , Atlanta , GA , USA.
2
b Division of Hematology, Department of Medicine , Brigham and Women's Hospital and Harvard Medical School , Boston , MA , USA.

Abstract

Platelet numbers are intricately regulated to avoid spontaneous bleeding or arterial occlusion and organ damage. The growth factor thrombopoietin (TPO) drives platelet biogenesis by inducing megakaryocyte production. A recent study in mice identified a feedback mechanism by which clearance of aged, desialylated platelets stimulates TPO synthesis by hepatocytes. This new finding generated renewed interest in platelet clearance mechanisms. Here, different established and emerging mechanisms of platelet senescence and clearance will be reviewed with specific emphasis on the role of posttranslational modifications.

KEYWORDS:

Ashwell-Morell receptor; GPIbα; platelet clearance; sialic acid

PMID:
27135356
PMCID:
PMC5396182
DOI:
10.3109/09537104.2016.1171304
[Indexed for MEDLINE]
Free PMC Article

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