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Trends Cancer. 2016 Apr;2(4):176-190.

Modeling pancreatic cancer with organoids.

Author information

1
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Lustgarten Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724, USA.
2
Hubrecht Institute and University Medical Centre Utrecht, Utrecht, The Netherlands.
3
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; Lustgarten Pancreatic Cancer Research Laboratory, Cold Spring Harbor, NY 11724, USA; Rubenstein Center for Pancreatic Cancer Research, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

Abstract

Pancreatic ductal adenocarcinoma (PDA) is a highly lethal malignancy for which new treatment and diagnostic approaches are urgently needed. In order for such breakthroughs to be discovered, researchers require systems that accurately model the development and biology of PDA. While cell lines, genetically engineered murine models, and xenografts have all led to valuable clinical insights, organotypic culture models have emerged as tractable systems to recapitulate the complex three-dimensional organization of PDA. Recently, multiple methods for modeling PDA using organoids have been reported. This review aims to summarize these organoid methods in the context of other PDA models. While each model system has unique benefits and drawbacks, ultimately, organoids hold special promise for the development of personalized medicine approaches.

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