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Brain Behav. 2016 Apr 22;6(6):e00473. doi: 10.1002/brb3.473. eCollection 2016 Jun.

Relationship between dyslipidemia and carotid plaques in a high-stroke-risk population in Shandong Province, China.

Author information

1
Neurology Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.
2
Cardio-Cerebrovascular Control and Research Center Institute of Basic Medicine Shandong Academy of Medical Sciences Jinan Shandong 250062 China.
3
Neurology Department Weifang Chinese Medicine Hospital Weifang Shandong 261041 China.
4
Neurosurgery Department Wayne State University School of Medicine Detroit Michigan 48201 China.
5
Medical Department Shandong Provincial Hospital Affiliated to Shandong University Jinan Shandong 250021 China.

Abstract

INTRODUCTION:

The precise associations between stroke and carotid plaques and dyslipidemia are unclear. This population-based study aimed to examine the relationship between carotid plaques and dyslipidemia in a high-stroke-risk population.

METHODS:

Ultrasonography of left and right carotid arteries was conducted in 22,222 participants in a second screening survey of individuals with high stroke risk. Subjects were divided into two groups according to the presence or absence of carotid plaques. Blood TC (total cholesterol), TG (total triglycerides), and LDL-C (low-density lipoprotein cholesterol) levels were recorded.

RESULTS:

Multivariate logistic regression analysis, controlled for gender, age, education, geographic region, smoking, exercise, and overweight (Model 2), identified TG as a predictor of carotid-plaque risk (odds ratio [OR] = 1.109, 95% confidence interval [CI]: 1.038-1.185, P = 0.002), and the association between carotid plaques and LDL-C (OR = 0.967, 95%CI: 0.949-0.994, P = 0.019) was less significant, whereas there was no association between carotid plaques and TC (OR = 1.002, 95%CI: 0.932-1.007, P = 0.958). After additional adjustment for hypertension, diabetes, and atrial fibrillation (Model 3), TG remained a risk factor for carotid plaques (OR = 1.086, 95%CI: 1.016-1.161, P = 0.015), but no associations were observed between carotid plaques and LDL-C (OR = 0.972, 95%CI: 0.910-1.038, P = 0.394) or TC (OR = 1.003, 95%CI: 0.933-1.079, P = 0.928). Only the association between TG and carotid plaques (OR = 1.084, 95%CI: 1.014-1.159, P = 0.017) was independent of all covariates (covariates in Model 3 plus history of stroke or transient ischemic attack, and stroke family history) in Model 4.

CONCLUSION:

These findings indicate that TG was an independent risk factor for carotid plaques in high-risk population for stroke, whereas LDL-C and TC were not associated with the appearance of carotid plaques independently.

KEYWORDS:

Carotid plaque; dyslipidemia; stroke

PMID:
27134771
PMCID:
PMC4842930
DOI:
10.1002/brb3.473
[Indexed for MEDLINE]
Free PMC Article

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