Format

Send to

Choose Destination
Semin Fetal Neonatal Med. 2016 Dec;21(6):418-423. doi: 10.1016/j.siny.2016.04.005. Epub 2016 Apr 25.

Microbial therapeutic interventions.

Author information

1
University of Chicago, Chicago, IL, USA.
2
Queen's University, Department of Medicine, Kingston General Hospital, Kingston, ON, Canada.
3
University of Chicago, Chicago, IL, USA. Electronic address: eclaud@peds.bsd.uchicago.edu.

Abstract

The microbiome comprises all the microbes living in and on the human body. Human cells are greatly outnumbered by bacterial cells; thus human health depends on the health of the microbial ecosystem. For the immature preterm infant, the microbiome also influences intestinal and immune system development. This has implications for short term morbidities such as neonatal necrotizing enterocolitis and sepsis, but also long term health outcomes. Optimization of the preterm infant microbiome is a growing topic of interest. The microbial world is not one of good versus evil, but rather one of community; thus optimization includes not only minimizing pathogens, but also enhancing beneficial organisms. Options for optimization include judicious antibiotic use, administration of supplements such as prebiotics or probiotics, and transfaunation procedures such as fecal microbial transplant or microbial ecosystem therapeutics. Potential for benefit as well as risk for each of these options will be discussed.

KEYWORDS:

Fecal microbial transplant; Microbial ecosystem therapeutics; Microbiome; Prebiotics; Probiotics

PMID:
27133778
PMCID:
PMC5079850
DOI:
10.1016/j.siny.2016.04.005
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center