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Arch Med Res. 2016 Feb;47(2):96-104. doi: 10.1016/j.arcmed.2016.04.003. Epub 2016 Apr 28.

Helicobacter pylori Infection Increases Frequency of PDCA-1(+) (CD317(+)) B-cell Subsets.

Author information

1
The First Hospital, Jilin University, Changchun, China.
2
The First Hospital, Jilin University, Changchun, China. Electronic address: liuyuanyuan1960@163.com.
3
The First Hospital, Jilin University, Changchun, China. Electronic address: yanfangjiang@hotmail.com.

Abstract

BACKGROUND AND AIMS:

As a newly discovered B-cell subset, PDCA-1(+) B cells have been shown to participate in the immune clearance of invading pathogens. The prominence of PDCA-1(+) B cell immunity in the pathogenesis of Helicobacter pylori infection prompted us to explore the potential role of this subset in gastric H. pylori infection.

METHODS:

H. pylori infection was determined by (14)C-urea breath test and Western blot. The frequency of the different sub-compartments of PDCA-1(+) B cells and their relation to serum cytokines was determined in 33 H. pylori-infected and 14 uninfected patients and in 12 healthy controls (HC).

RESULTS:

In comparison to uninfected individuals, there was a significantly increased frequency of PDCA-1(+) B cells, PDCA-1(+)IgM(+) B cells, CD93(+)PDCA-1(+) B cells, CD93(+)PDCA-1(+)IgM(+) B cells, CD137(+)PDCA-1(+) B cells and CD137(+)PDCA-1(+)IgM(+) B cells were detected in patients with H. pylori infection, corresponding to increased levels of serum IFN-α and IgM in this group. Compared with H. pylori-positive (HP(+)) chronic non-atrophic gastritis patients, a larger proportion of PDCA-1(+) B cells, CD93(+)PDCA-1(+) B cells and CD137(+)PDCA-1(+) B cells were observed in HP(+) patients suffering from atrophic gastritis or HP(+) peptic ulcers.

CONCLUSIONS:

The frequency of the PDCA-1(+) B cell compartment is increased during H. pylori infection. Our data support the potential role of this B-cell subset in the pathogenesis of H. pylori-dependent gastritis.

KEYWORDS:

Gastritis; Helicobacter pylori; IFN-α; IgM; PDCA-1(+) B cells

PMID:
27133710
DOI:
10.1016/j.arcmed.2016.04.003
[Indexed for MEDLINE]

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