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Transplant Rev (Orlando). 2016 Jul;30(3):119-43. doi: 10.1016/j.trre.2016.04.001. Epub 2016 Apr 29.

Management of cytomegalovirus infection in solid organ transplant recipients: SET/GESITRA-SEIMC/REIPI recommendations.

Author information

1
Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sofía-IMIBIC-UCO, Cordoba. Spain; Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain. Electronic address: julian.torre@sspa.juntadeandalucia.es.
2
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre (i+12) University Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain. Electronic address: jaguadog1@gmail.com.
3
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Unit of Infectious Diseases, Hospital General Universitario, Universidad de Castilla La Mancha, Ciudad Real, Spain.
4
Servicio de Cardiología, Unidad de Insuficiencia Cardiaca y Trasplante, Hospital Universitario y Politécnico, Valencia, Spain.
5
Servicio de Nefrología, Hospital Universitario, A Coruña, Spain.
6
Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sofía-IMIBIC-UCO, Cordoba. Spain.
7
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Department of Infectious Diseases, Bellvitge Hospital-IDIBELL, University of Barcelona, Spain.
8
Department of Medicine, Division of Infectious Diseases, University of Alberta, Edmonton, Canada.
9
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Infectious Diseases Department, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
10
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Unidad de Enfermedades Infecciosas, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain.
11
Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre (i+12) University Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain.
12
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Madrid, Spain.
13
Servicio de Hepatología y Trasplante Hepático, Hospital Universitario Infantil La Paz, Madrid, Spain.
14
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Deparment of Infectious Diseases, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, Barcelona, Spain.
15
Servicio de Nefrología, Hospital Universitario Carlos Haya, Málaga, Spain.
16
Unidad de Hepatología, Clinica Universitaria de Navarra, CIBERehd, Instituto de Investigación Sanitaria de Navarra, Pamplona, Spain.
17
Servicio de Cardiología, Hospital Universitario de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain.
18
Department of Clinical Microbiology, Hospital Clinic, Universidad de Barcelona, ISGlobal Barcelona Institute for Global Health, Barcelona, Spain.
19
Servicio de Enfermedades Infecciosas, Hospital Ramón y Cajal, Madrid, Spain.
20
Servicio de Neumología, Hospital Universitari Vall d'Hebron, CIBER Enfermedades Respiratorias (CIBERES), Barcelona, Spain.
21
Unidad de Enfermedades Infecciosas, Hospital Universitario de Cruces, Bilbao, Spain.
22
Deparment of Infectious Diseases, Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain.
23
Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Instituto de Investigación Sanitario Gregorio Marañon, Madrid, Spain.
24
Department of Microbiology, Hospital Clínico Universitario, Fundación para la Investigación del Hospital Clínico Universitario de Valencia (INCLIVA), Valencia, Spain. Department of Microbiology, Universitat de València, Valencia, Spain.
25
Instituto de Biomedicina de Sevilla (IBIS), Unit of Infectious Diseases, Microbiology and Preventive Medicine, University Hospital Virgen del Rocío/CSIC/University of Sevilla, Sevilla, Spain.
26
Servicio de Nefrología, Hospital Universitario Reina Sofía, Córdoba, Spain.
27
Unidad de Infectología Pediátrica, UGC Pediatría, Hospital Universitario Reina Sofía, Córdoba, Spain.
28
Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain; Unit of Infectious Diseases, Instituto de Investigación Hospital 12 de Octubre (i+12) University Hospital 12 de Octubre, Universidad Complutense, Madrid, Spain.
29
Unidad de Neumología, Cirugía Torácica y Trasplante Pulmonar, Hospital Universitario Reina Sofía, Córdoba, Spain.
30
Clinical Unit of Infectious Diseases, Hospital Universitario Reina Sofía-IMIBIC-UCO, Cordoba. Spain; Spanish Network for Research in Infectious Diseases (REIPIRD12/0015), Instituto de Salud Carlos III, Madrid, Spain.

Abstract

Cytomegalovirus (CMV) infection remains a major complication of solid organ transplantation. Because of management of CMV is variable among transplant centers, in 2011 the Spanish Transplantation Infection Study Group (GESITRA) of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) developed consensus guidelines for the prevention and treatment of CMV infection in solid organ transplant recipients. Since then, new publications have clarified or questioned the aspects covered in the previous document. For that reason, a panel of experts revised the evidence on CMV management, including immunological monitoring, diagnostics, prevention, vaccines, indirect effects, treatment, drug resistance, immunotherapy, investigational drugs, and pediatric issues. This document summarizes the recommendations.

PMID:
27132815
DOI:
10.1016/j.trre.2016.04.001
[Indexed for MEDLINE]

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