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Urol Clin North Am. 2016 May;43(2):223-32. doi: 10.1016/j.ucl.2016.01.009. Epub 2016 Mar 21.

Testosterone and Varicocele.

Author information

1
Department of Urology, Massachusetts General Hospital, 55 Fruit Street, GRB 1102, Boston, MA 02114, USA.
2
Department of Urology, Massachusetts General Hospital, 55 Fruit Street, GRB 1102, Boston, MA 02114, USA. Electronic address: ctanrikut@mgh.harvard.edu.

Abstract

Varicocele is defined as an excessive dilation of the pampiniform plexus. The association between varicocele and infertility has been well-established as evidenced by negative effects on spermatogenesis. Accumulating evidence now suggests that varicocele presents a pantesticular insult, with resultant impairment of Leydig cell function. The presence of a varicocele has been linked to lower serum testosterone levels and varicocelectomy may reverse some of the adverse effects on androgen production. In this review, the evidence linking varicoceles to impaired steroidogenesis and which cohorts of men may benefit most from varicocele repair are discussed.

KEYWORDS:

Androgen receptor; Erectile dysfunction; Hypogonadism; Leydig cell; Steroidogenesis; Testosterone; Varicocele; Varicocelectomy

PMID:
27132580
DOI:
10.1016/j.ucl.2016.01.009
[Indexed for MEDLINE]

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