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Haematologica. 2016 May;101(5):531-40. doi: 10.3324/haematol.2015.139493.

Role of the tumor microenvironment in mature B-cell lymphoid malignancies.

Author information

1
Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA nfowler@mdanderson.org.
2
Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA Department of Haematology, Pathwest Laboratory Medicine WA and Sir Charles Gairdner Hospital, Perth, Western Australia University of Western Australia, Perth, Canada.
3
British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada.
4
Department of Haemato-Oncology, Barts Cancer Institute, London, UK.
5
Department of Lymphoma/Myeloma, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
6
Università Vita-Salute San Raffaele, Division of Experimental Oncology, IRCCS Istituto Scientifico San Raffaele, Milan, Italy Department of Onco-Hematology, Ospedale San Raffaele, Milan, Italy.
7
Children's Research Institute, Washington, DC, USA.
8
Division of Hematology, Mayo Clinic, Rochester, MN, USA.
9
Lymphoid Malignancies Branch, National Cancer Institute, Bethesda, MD, USA.
10
University of California, Irvine, CA, USA.
11
St. James' Hospital, Dublin, Ireland.
12
Cancer Therapeutic Evaluation Program, National Cancer Institute, Bethesda, MD, USA.
13
University of Heidelberg, Germany.

Abstract

The tumor microenvironment is the cellular and molecular environment in which the tumor exists and with which it continuously interacts. In B-cell lymphomas, this microenvironment is intriguing in that it plays critical roles in the regulation of tumor cell survival and proliferation, fostering immune escape as well as the development of treatment resistance. The purpose of this review is to summarize the proceedings of the Second Annual Summit on the Immune Microenvironment in Hematologic Malignancies that took place on September 11-12, 2014 in Dublin, Ireland. We provide a timely overview of the composition and biological relevance of the cellular and molecular microenvironment interface and discuss the role of interactions between the microenvironment and neoplastic cells in a variety of B-cell lymphomas. In addition, we focus on various novel therapeutic strategies that target the tumor microenvironment, including agents that modulate B-cell receptor pathways and immune-checkpoints, chimeric antigen receptor T cells and immunomodulatory agents.

PMID:
27132279
PMCID:
PMC5004369
DOI:
10.3324/haematol.2015.139493
[Indexed for MEDLINE]
Free PMC Article

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