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Trends Endocrinol Metab. 2016 Jul;27(7):439-440. doi: 10.1016/j.tem.2016.04.010. Epub 2016 Apr 27.

CMPF: A Biomarker for Type 2 Diabetes Mellitus Progression?

Author information

1
Montreal Diabetes Research Center, CRCHUM, Montreal, QC, Canada.
2
Montreal Diabetes Research Center, CRCHUM, Montreal, QC, Canada; Department of Medicine, University of Montreal, Montreal, QC, Canada. Electronic address: vincent.poitout@umontreal.ca.

Abstract

The factors that precipitate the transition from insulin resistance to type 2 diabetes mellitus (T2DM) remain elusive. A recent study showed that circulating levels of the furan fatty acid (FA) metabolite 3-Carboxy-4-Methyl-5-Propyl-2-Furanopropanoic Acid (CMPF) increase in individuals who progress from prediabetes to T2DM. CMPF increases oxidative stress and impairs insulin granule maturation and secretion.

PMID:
27132217
DOI:
10.1016/j.tem.2016.04.010
[Indexed for MEDLINE]

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