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AIDS Res Hum Retroviruses. 1989 Apr;5(2):131-8.

Augmentation of human immunodeficiency virus type 1 gene expression by tumor necrosis factor alpha.

Author information

1
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.

Abstract

It is now well established that cytokines are involved in the regulation of gene expression from HIV-1 LTR. The present study provides evidence that TNF-alpha stimulates HIV-1 gene expression and that the enhancer sequence within the HIV-1 LTR is involved in the stimulation. These results support the idea that immunologic stimulation and infection may trigger the development of clinical AIDS in individuals latently infected with HIV-1.

PMID:
2713164
DOI:
10.1089/aid.1989.5.131
[Indexed for MEDLINE]

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