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Curr Opin Neurobiol. 2016 Aug;39:53-61. doi: 10.1016/j.conb.2016.04.004. Epub 2016 Apr 29.

A role for the survival of motor neuron protein in mRNP assembly and transport.

Author information

1
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA.
2
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA; Department of Neurology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: gbassel@emory.edu.
3
Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA. Electronic address: wrossol@emory.edu.

Abstract

Localization and local translation of mRNA plays a key role in neuronal development and function. While studies in various systems have provided insights into molecular mechanisms of mRNA transport and local protein synthesis, the factors that control the assembly of mRNAs and mRNA binding proteins into messenger ribonucleoprotein (mRNP) transport granules remain largely unknown. In this review we will discuss how insights on a motor neuron disease, spinal muscular atrophy (SMA), is advancing our understanding of regulated assembly of transport competent mRNPs and how defects in their assembly and delivery may contribute to the degeneration of motor neurons observed in SMA and other neurological disorders.

PMID:
27131421
DOI:
10.1016/j.conb.2016.04.004
[Indexed for MEDLINE]

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