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Biol Chem Hoppe Seyler. 1989 Jan;370(1):35-40.

Carnivora: the primary structure of the giant otter (Pteronura brasiliensis, Mustelidae) hemoglobin.

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Max-Planck-Institut für Biochemie, Abteilung Proteinchemie, Martinsried bei München.


The hemoglobin of the Giant Otter (Pteronura brasiliensis, Carnivora) contains only one component. The complete primary structures of the alpha- and beta-chains are presented. The globin chains were separated by high-performance liquid chromatography and the sequences determined by automatic liquid- and gas-phase Edman degradation of the chains and their tryptic peptides. The alpha-chains show 18 and the beta-chains 12 exchanges compared with human alpha- and beta-chains, respectively. In the alpha-chains, two substitutions involve alpha 1/beta 1-contacts and one a heme-contact. In the beta-chains one alpha 1/beta 1-, one alpha 1/beta 2- and one heme-contact are exchanged. The alpha- and beta-chains of the Giant Otter are compared to those of the Common Otter and other Carnivora hemoglobins.

[Indexed for MEDLINE]

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