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Trends Neurosci. 2016 Jun;39(6):353-355. doi: 10.1016/j.tins.2016.04.004. Epub 2016 Apr 26.

Neuroinflammation Regulates Cognitive Impairment in Socially Defeated Mice.

Author information

1
Fishberg Department of Neuroscience and Friedman Brain Institute; Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, NY, NY 10029, USA.
2
Fishberg Department of Neuroscience and Friedman Brain Institute. Electronic address: scott.russo@mssm.edu.

Abstract

Impairments in memory and cognitive function are characteristic symptoms of stress-related disorders, but the relationship between stress and memory is complex. Recent findings suggest that hippocampal inflammatory processes contribute to spatial memory deficits in the rodent social defeat model that can be reversed by anti-inflammatory treatment with minocycline.

KEYWORDS:

Inflammation; memory; neurogenesis; stress

PMID:
27130658
PMCID:
PMC4884537
DOI:
10.1016/j.tins.2016.04.004
[Indexed for MEDLINE]
Free PMC Article

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