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J Dermatol. 2016 Oct;43(10):1205-1208. doi: 10.1111/1346-8138.13416.

Presenile diffuse familial sebaceous hyperplasia successfully treated with low-dose isotretinoin: A report of two cases and review of the published work.

Author information

1
Department of Dermatology, Hsinchu Cathay General Hospital, Hsinchu City, Taiwan.
2
Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan.
3
Department of Dermatology, National Taiwan University Hospital, Taipei City, Taiwan.
4
Department of Dermatology, National Taiwan University Hospital Hsinchu Branch, Hsinchu City, Taiwan.
5
Department of Dermatology, Chang-Gung Memorial Hospital, Taipei City, Taiwan.
6
Department of Dermatology, Cathay General Hospital, Taipei City, Taiwan. yangchiayi@gmail.com.
7
Department of Dermatology, National Taiwan University Hospital, Taipei City, Taiwan. yangchiayi@gmail.com.

Abstract

Presenile diffuse familial sebaceous hyperplasia (PDFSH) presents as extensive yellowish papules with central umbilication on the face without involvement of periorificial regions and occurs in adolescents or young adults with a positive family history. Thirteen cases of PDFSH have been reported in the English-language published work, 10 of which responded to oral isotretinoin from 0.5 to 1 mg/kg per day but recurrences were often observed. Herein, we report two cases of PDFSH, which were successfully managed without recurrence with prolonged low-dose isotretinoin (0.2 mg/kg per day, a cumulative dose of 41 and 64 mg/kg, respectively). Treatment protocols among different published works were reviewed to verify the efficacy of isotretinoin.

KEYWORDS:

androgen; familial presenile sebaceous gland hyperplasia; isotretinoin; sebaceous gland diseases; sebaceous glands

PMID:
27130181
DOI:
10.1111/1346-8138.13416
[Indexed for MEDLINE]

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