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Clin Sci (Lond). 2016 Jun 1;130(11):843-52. doi: 10.1042/CS20150780.

Mitochondrial dynamics, quality control and miRNA regulation in skeletal muscle: implications for obesity and related metabolic disease.

Author information

1
Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.
2
Department of Human Biology and Human Movement Sciences, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands j.hoeks@maastrichtuniversity.nl.

Abstract

The western dietary habits and sedentary lifestyle largely contributes to the growing epidemic of obesity. Mitochondria are at the front line of cellular energy homoeostasis and are implicated in the pathophysiology of obesity and obesity-related metabolic disease. In recent years, novel aspects in the regulation of mitochondrial metabolism, such as mitochondrial dynamics, mitochondrial protein quality control and post-transcriptional regulation of genes coding for mitochondrial proteins, have emerged. In this review, we discuss the recent findings concerning the dysregulation of these processes in skeletal muscle in obesogenic conditions.

KEYWORDS:

metabolic disease; microRNAs; mitochondria; obesity; skeletal muscle

PMID:
27129097
DOI:
10.1042/CS20150780
[Indexed for MEDLINE]

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