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J Nucl Med. 2016 Sep;57(9):1370-5. doi: 10.2967/jnumed.115.168575. Epub 2016 Apr 28.

Left Ventricular Function Assessment Using 2 Different Cadmium-Zinc-Telluride Cameras Compared with a γ-Camera with Cardiofocal Collimators: Dynamic Cardiac Phantom Study and Clinical Validation.

Author information

1
Nuclear Medicine, IRIS, Polyclinique du Bois, Lille, France Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France Normandie Université-EA4650, Caen, France abailliez@gmail.com.
2
Nuclear Medicine, CHU de Toulouse, Toulouse, France.
3
Nuclear Medicine, Centre Jean Perrin, Clermont-Ferrand, France.
4
Nuclear Medicine, CHU de Nantes, Nantes, France.
5
Normandie Université-EA4650, Caen, France Cardiology, CHU de Caen, Caen, France; and.
6
Nuclear Medicine, IRIS, Polyclinique du Bois, Lille, France Nuclear Medicine, UF 5881, Groupement des Hôpitaux de l'Institut Catholique de Lille, Lomme, France Normandie Université-EA4650, Caen, France.
7
Normandie Université-EA4650, Caen, France Nuclear Medicine, CHU de Caen, Caen, France.

Abstract

This study compared two SPECT cameras with cadmium-zinc-telluride (CZT) detectors to a conventional Anger camera with cardiofocal collimators for the assessment of left ventricular (LV) function in a phantom and patients.

METHODS:

A gated dynamic cardiac phantom was used. Eighteen acquisitions were processed on each CZT camera and the conventional camera. The total number of counts within a myocardial volume of interest varied from 0.25 kcts to 1.5 Mcts. Ejection fraction was set to 33%, 45%, or 60%. Volume, LV ejection fraction (LVEF), regional wall thickening, and motion (17-segment model) were assessed. One hundred twenty patients with a low pretest likelihood of coronary artery disease and normal findings on stress perfusion SPECT were retrospectively analyzed to provide the reference limits for end-diastolic volume (EDV), end-systolic volume (ESV), ejection fraction, and regional function for each camera model.

RESULTS:

In the phantom study, for each ejection fraction value, volume was higher for the CZT cameras than for the conventional camera, resulting in a decreased but more accurate LVEF (all P < 0.001). In clinical data, body-surface-indexed EDV and ESV (mL/m(2)) were higher for one of the CZT cameras (Discovery NM 530c) than for the other (D-SPECT) or the conventional camera (respectively, 40.5 ± 9.2, 37 ± 7.9, and 35.8 ± 6.8 for EDV [P < 0.001] and 12.5 ± 5.3, 9.4 ± 4.2, and 8.3 ± 4.4 for ESV [P < 0.001]), resulting in a significantly decreased LVEF: 70.3% ± 9.1% vs. 75.2% ± 8.1% vs. 77.8% ± 9.3%, respectively (P < 0.001).

CONCLUSION:

The new CZT cameras yielded global LV function results different from those yielded by the conventional camera. LV volume was higher for the Discovery NM 530c than for the D-SPECT or the conventional camera, leading to decreased LVEF in healthy subjects. These differences should be considered in clinical practice and warrant the collection of a specific reference database.

KEYWORDS:

CZT; cardiofocal collimators; dynamic phantom; left ventricular function; myocardial perfusion imaging; wall thickening

PMID:
27127220
DOI:
10.2967/jnumed.115.168575
[Indexed for MEDLINE]
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