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Adv Healthc Mater. 2016 Aug;5(15):1861-7. doi: 10.1002/adhm.201600295. Epub 2016 Apr 29.

Mimicking Tissue Boundaries by Sharp Multiparameter Matrix Interfaces.

Author information

1
Institute of Biochemistry, Universität Leipzig, 04103, Leipzig, Germany.

Abstract

Engineering interfaces of distinct extracellular compartments mimicking native tissues are key for in-depth in vitro studies on developmental and disease processes in biology and medicine. Sharp interfaces of extracellular matrices are constructed based on fibrillar collagen I networks with a multiparameter control of topology, mechanics, and composition, and their distinct impact on triggering the directionality of cancer cell migration is demonstrated.

KEYWORDS:

biomaterials; biopolymer networks; cancer cell migration; matrix engineering; matrix interfaces

PMID:
27125887
DOI:
10.1002/adhm.201600295
[Indexed for MEDLINE]

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