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Epidemiol Infect. 2016 Jun;144(8):1634-40. doi: 10.1017/S0950268815003064.

The treatment of HCV in patients with haemoglobinopathy in Kurdistan Region, Iraq: a single centre experience.

Author information

1
Department of Internal Medicine,School of Medicine, Faculty of Medical Sciences,University of Duhok,Kurdistan Region,Iraq.
2
Fatih University,Faculty of Science,Department of Biology,Istanbul,Turkey.
3
Microbiology and Biotechnology Research Laboratory,Department of Environmental Sciences,Fatima Jinnah Women University,Rawalpindi,Pakistan.
4
Department of Health,Infection Control Unit,Duhok,Iraq.
5
Department of Microbiology,University Hospital,Queen's Medical Centre,Nottingham,UK.

Abstract

Various variables that might influence the rapid and sustained virological response to recombinant PEG-IFN-α-2a were explored in Iraqi HCV-infected patients with haemoglobinopathy. Forty-three patients were evaluated for the relationship between rapid virological response (RVR), IL-28B polymorphism, viral load, liver enzyme levels, blood group, ultrasound findings, or HCV genotype and the sustained virological response (SVR) achievement. The overall RVR was 55·81% while the overall SVR was 53·49%. SVR in patients that achieved RVR was 82·61% (P = 0·0004). A significant association was found between initial alanine transaminase levels and viral load with SVR achievement (P = 0·025) and (P = 0·004), respectively. Thirty-two (74%) out of 43 of our samples were host genotyped at the IL-28B locus as CC, a significant association was found between CC group and SVR achievement (P = 0·04). Of our samples, 23/43 (53%) were typed as HCV genotype 4, 10/43 (23%) as genotype 1, 9/43 (20·9%) as genotype 3 and 1/43 (2·3%) as genotype 2. A significant association was found between genotype 3 and SVR achievement (P = 0·006). Multivariate analysis showed that only RVR achievement independently associated with SVR in the Iraqi population (P = 0·00). These results can be used to classify the patients requiring the more expensive new direct-acting antiviral drugs.

KEYWORDS:

HCV; Haemoglobinopathy; Iraqi population; RVR; SVR

PMID:
27125573
DOI:
10.1017/S0950268815003064
[Indexed for MEDLINE]

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