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Epidemiol Infect. 2016 Jun;144(8):1634-40. doi: 10.1017/S0950268815003064.

The treatment of HCV in patients with haemoglobinopathy in Kurdistan Region, Iraq: a single centre experience.

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Department of Internal Medicine,School of Medicine, Faculty of Medical Sciences,University of Duhok,Kurdistan Region,Iraq.
Fatih University,Faculty of Science,Department of Biology,Istanbul,Turkey.
Microbiology and Biotechnology Research Laboratory,Department of Environmental Sciences,Fatima Jinnah Women University,Rawalpindi,Pakistan.
Department of Health,Infection Control Unit,Duhok,Iraq.
Department of Microbiology,University Hospital,Queen's Medical Centre,Nottingham,UK.


Various variables that might influence the rapid and sustained virological response to recombinant PEG-IFN-α-2a were explored in Iraqi HCV-infected patients with haemoglobinopathy. Forty-three patients were evaluated for the relationship between rapid virological response (RVR), IL-28B polymorphism, viral load, liver enzyme levels, blood group, ultrasound findings, or HCV genotype and the sustained virological response (SVR) achievement. The overall RVR was 55·81% while the overall SVR was 53·49%. SVR in patients that achieved RVR was 82·61% (P = 0·0004). A significant association was found between initial alanine transaminase levels and viral load with SVR achievement (P = 0·025) and (P = 0·004), respectively. Thirty-two (74%) out of 43 of our samples were host genotyped at the IL-28B locus as CC, a significant association was found between CC group and SVR achievement (P = 0·04). Of our samples, 23/43 (53%) were typed as HCV genotype 4, 10/43 (23%) as genotype 1, 9/43 (20·9%) as genotype 3 and 1/43 (2·3%) as genotype 2. A significant association was found between genotype 3 and SVR achievement (P = 0·006). Multivariate analysis showed that only RVR achievement independently associated with SVR in the Iraqi population (P = 0·00). These results can be used to classify the patients requiring the more expensive new direct-acting antiviral drugs.


HCV; Haemoglobinopathy; Iraqi population; RVR; SVR

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