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Pediatr Diabetes. 2017 Aug;18(5):332-339. doi: 10.1111/pedi.12395. Epub 2016 Apr 29.

In-home nighttime predictive low glucose suspend experience in children and adults with type 1 diabetes.

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Barbara Davis Center for Childhood Diabetes, University of Colorado Denver, Aurora, CO, USA.
Jaeb Center for Health Research, Tampa, FL, USA.
Division of Endocrinology and Diabetes, Stanford School of Medicine, Palo Alto, CA, USA.
Division of Endocrinology and Metabolism, St Joseph's Health Care, London, ON, Canada.
Diabetes Clinical Trials Unit, St. Joseph's Health Care London, London, ON, Canada.


Overnight predictive low glucose suspend (PLGS) reduces hypoglycemia across all ages; however, there are no reports on behavior or experience differences across age groups, especially in pediatrics. As run-in for a subsequent randomized clinical trial (RCT), 127 subjects (50% male) ages 4-45 yr utilized the experimental PLGS system nightly for 5-10 nights (PLGS active phase). We analyzed the number of blood glucose (BG) checks and boluses given per age group. During the subsequent 42 night RCT phase, we analyzed sensor use, skin reactions, errors, and reasons why the experimental system was not used. In 821 nights of active PLGS, subjects ages 4-6 yr (and their parents) tested BG levels 75% of nights compared with 65% of nights (7-10 yr), 53% of nights (11-14 yr), 33% of nights (15-25 yr), and 28% of nights (26-45 yr), respectively (p < 0.001). Likewise, youngest subjects (and parents) administered insulin boluses 56% of nights during active PLGS use compared with 48%, 33%, 20%, and 25%, respectively (p < 0.001). This was unrelated to study requirements. During the RCT phase, subjects 4-6 yr experienced more frequent and severe skin reactions (p = 0.02), while adult subjects (26-45 yr) wore individual sensors a median of 26 h longer than the youngest subjects (p < 0.001). Technical problems with the sensor (errors, miscalibrations, etc.), traveling, and BG levels >270 at bedtime (study requirement) were primary contributors to non-system use. Understanding the different use patterns and challenges in pediatrics and adolescence is needed to direct patient education to optimize use of PLGS and future artificial pancreas systems.


artificial pancreas; pediatrics; type 1 diabetes

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