The three-dimensional representation is used by cerebral blood flow SPECT and myocardial SPECT. It is used with the statistical image analysis software (3D-SSP, eZIS) in cerebral blood flow SPECT, and regional cerebral blood flow decrease can be detected. It is used with the heart function analysis software (QGS, QPS, QBS) in myocardial SPECT, and is effective for the cardiac wall motion evaluation. SPECT/CT and PET/CT are used in clinical. The three-dimensional fusion image that overlaps CT- volume rendering image with SPECT (PET) image can be constructed with an easy and high quality by SPECT/CT (PET/CT). It is effective for identification of accumulation part of radiopharmaceutical.