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Medicine (Baltimore). 2016 Apr;95(17):e3379. doi: 10.1097/MD.0000000000003379.

The Association Between Glycosylation of Immunoglobulin G and Hypertension: A Multiple Ethnic Cross-Sectional Study.

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From Beijing Key Laboratory of Clinical Epidemiology, School of Public Health, Capital Medical University, Beijing, China (YW, XY, SG, LW, MS, JZ, XG, WW); Genos Glycoscience, Zagreb, Croatia (LK, KT, MN, JK, MP-B, IU, GL); MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK (LK); School of Medical Sciences, Edith Cowan University, Perth, WA, Australia (YW, XY, SG, WW); Center for Physical Examination, Xuanwu Hospital, Capital Medical University, Beijing, China (JD, YL); Centre for Population Health Sciences, Medical School, University of Edinburgh, Edinburgh, UK (JW, IR, HC); Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia (OP, GL); Department of Neurology, Beijing Anzhen Hospital, Capital Medical University (YZ); International Medical Centre, Chinese PLA General Hospital, Beijing, China (QZ); Institute of Cytology and Genetics SB RAS (YA); and Novosibirsk State University, Novosibirsk, Russia (YA).


More than half of all known proteins, and almost all membrane and extra-cellular proteins have oligosaccharide structures or glycans attached to them. Defects in glycosylation pathways are directly involved in at least 30 severe human diseases.A multiple center cross-sectional study (China, Croatia, and Scotland) was carried out to investigate the possible association between hypertension and IgG glycosylation. A hydrophilic interaction chromatography of fluorescently labeled glycans was used to analyze N-glycans attached to IgG in plasma samples from a total of 4757 individuals of Chinese Han, Croatian, and Scottish ethnicity.Five glycans (IgG with digalactosylated glycans) significantly differed in participants with prehypertension or hypertension compared to those with normal blood pressure, while additional 17 glycan traits were only significantly differed in participants with hypertension compared to those of normal blood pressure. These glycans were also significant correlated with systolic blood pressure (SBP) or diastolic blood pressure (DBP).The present study demonstrated for the 1st time an association between hypertension and IgG glycome composition. These findings suggest that the individual variation in N-glycosylation of IgG contributes to pathogenesis of hypertension, presumably via its effect on pro- and/or anti-inflammatory pathways.

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