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PLoS One. 2016 Apr 28;11(4):e0153691. doi: 10.1371/journal.pone.0153691. eCollection 2016.

Discordant Expression of Circulating microRNA from Cellular and Extracellular Sources.

Author information

1
Cardiovascular Institute, Beth Israel Deaconess Medical Center, Boston, MA, 02215, United States of America.
2
University of Massachusetts Medical School, Department of Medicine, Division of Cardiovascular Medicine, Worcester, MA, 01605, United States of America.
3
The Framingham Heart Study, Framingham, MA, United States of America and Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, United States of America.
4
Yale University Medical School, Computational Biology & Bioinformatics Program, New Haven, CT, 06520, United States of America.
5
University of Massachusetts Medical School, Department of Quantitative Health Sciences, Worcester, MA, 01605, United States of America.
6
Department of Cardiology, University of Michigan, Ann Arbor, Michigan, 1500 E. Medical Center Dr. SPC 5873, Ann Arbor, MI, 48109, United States of America.

Abstract

MicroRNA (miRNA) expression has rapidly grown into one of the largest fields for disease characterization and development of clinical biomarkers. Consensus is lacking in regards to the optimal sample source or if different circulating sources are concordant. Here, using miRNA measurements from contemporaneously obtained whole blood- and plasma-derived RNA from 2391 individuals, we demonstrate that plasma and blood miRNA levels are divergent and may reflect different biological processes and disease associations.

PMID:
27123852
PMCID:
PMC4849639
DOI:
10.1371/journal.pone.0153691
[Indexed for MEDLINE]
Free PMC Article

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